RESUMO
Primary neuroprotective properties of new inhibitor of Naâº/⺠exchanger (compound RU-1355) were established on the model of 60-min focal ischemia of the left middle cerebral artery followed by 24-h reperfusion in rats. Compound RU-1355 significantly (by 34%) decreased neurological symptoms, reduced (1.67 times) the growth of neuron-specific enolase level in serum, decreased (2.3 times) the size of the necrotic zone, and reduced by 59% (p <0.05) the degree of cerebral edema According to the results of morphometric, immunoassay, and neurological assessments of brain damage, compound RU-1355 is superior on ave- rage by 43.5% (p < 0.05) in comparison to selective NHE1 inhibitor zoniporide.
Assuntos
Benzimidazóis/farmacologia , Edema Encefálico/tratamento farmacológico , Isquemia Encefálica/tratamento farmacológico , Transtornos Cerebrovasculares/tratamento farmacológico , Fármacos Neuroprotetores/farmacologia , Traumatismo por Reperfusão/tratamento farmacológico , Trocador 1 de Sódio-Hidrogênio/antagonistas & inibidores , Animais , Animais não Endogâmicos , Benzimidazóis/síntese química , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Encéfalo/fisiopatologia , Edema Encefálico/genética , Edema Encefálico/metabolismo , Edema Encefálico/fisiopatologia , Isquemia Encefálica/genética , Isquemia Encefálica/metabolismo , Isquemia Encefálica/fisiopatologia , Artérias Cerebrais/cirurgia , Transtornos Cerebrovasculares/genética , Transtornos Cerebrovasculares/metabolismo , Transtornos Cerebrovasculares/fisiopatologia , Feminino , Expressão Gênica , Guanidinas/farmacologia , Fármacos Neuroprotetores/síntese química , Fosfopiruvato Hidratase/sangue , Fosfopiruvato Hidratase/genética , Desempenho Psicomotor/efeitos dos fármacos , Pirazóis/farmacologia , Ratos , Traumatismo por Reperfusão/genética , Traumatismo por Reperfusão/metabolismo , Traumatismo por Reperfusão/fisiopatologia , Trocador 1 de Sódio-Hidrogênio/genética , Trocador 1 de Sódio-Hidrogênio/metabolismoRESUMO
Analyzing many year's data on the prevalence of giardiasis among Volgograd dwellers indicated that the five-year infectivity index did not substantially change and it was 6.3 +/- 0.4%. The rate of Giardia lamblia isolation was higher in healthy individuals in the high-loaded environmental topodemic regions of the city than in those in the good ones. Over 50% of all the cases of giardiasis were recorded among 7-15-year-old children, the proportion of preschool children was much less (31.9%). The rate of giardiasis detection in children who went to children's preschool facilities was twice higher than that in the unorganized population. The focality index was 6.8%, which is indicative of the low contagiousness of the disease.
